Data from 2,000 cancer genomes to be jointly analyzed using uniform algorithms.
CARLSBAD, CA – February 12, 2014 – Annai Systems Inc., a provider of genomic data management solutions, today announced that it has partnered with the Ontario Institute for Cancer Research (OICR) and the International Cancer Genome Consortium (ICGC) to provide its Annai GNOS™ data management software in support of six data centers around the world that will house a large data set for the Pan Cancer Project.
The Pan Cancer Project is an international effort to enable the further improvement and standardization of data analysis methods, including somatic mutation calling pipelines. This project is part of ICGC’s continued focus on generating comprehensive catalogues of genomic abnormalities in tumors from 50 different cancer types and/or subtypes.
The Pan Cancer data set consists of 2,000 whole genome tumor-normal pairs, on many of which transcriptome, DNA methylation and other analysis has been performed. The intention of the project is to define and organize a core analysis package that will be run for each cancer-normal whole genome pair. The sequence and associated data will be uploaded to one of six cloud computing facilities, where alignment to the reference human genome will be performed and basic variant calling algorithms run. These analyses will generate VCF format files containing all somatic mutations identified from the major classes of variants (substitutions, small indels, genomic rearrangements, copy number, retrotranspositions). Many multi-national bioinformatics teams will perform downstream analysis on these somatic mutations with the objective of arriving at one standard analytic pipeline.
Annai Systems’ software will be used initially by the cloud computing facilities to upload, store, provide access to and manage approximately one petabyte of data that will be replicated at six prominent data centers around the world.
“We selected Annai Systems as our data management partner based on their previous work with the Cancer Genome Hub (CGHub), which currently houses the Cancer Genome Atlas (TCGA) data,” commented Dr. Lincoln Stein, Director of OICR’s Informatics and Bio-Computing Program and Director of the ICGC’s Data Coordination Centre housed in Toronto, Canada. “It was important to be able to rapidly establish these data centers and ensure that the data could be securely uploaded and stored, and easily queried and accessed by a number of researchers. Annai’s GNOS platform was the ideal solution for this project,” added Stein.
“Our partnership with OICR and ICGC represents the next step in the evolution of Annai Systems as the premiere provider of genomic data management software solutions,” said Michael Penley, Annai’s Chief Executive Officer. “We are proud to have been chosen to provide the infrastructure and support for this important project and to work with these leading organizations in advancing cancer research and genomic-based medicine.”
About Annai Systems
Annai Systems is a leading genomic data analysis company committed to developing cost-reducing innovations the accelerate scientific discovery, maximize statistical power, and optimize data control. From data compression and storage to secondary and tertiary analysis, Annai Systems offers a true end-to-end solution designed to handle the complex needs of next-generation sequencing data in the clinical, pharmaceutical and research environments. The company’s flagship product, STARPlatform, enables researchers to innovate, collaborate, and make new discoveries – all in less time and at lower costs than traditional solutions. For more about Annai Systems, visit www.annaisystems.com.